Phospho-adducin distribution in a murine transgenic model of amyotrophic lateral sclerosis
Simon Fraser University Institutional Repository
View Archive Info| Field | Value | |
| Creator |
Shan, Xiao Yang
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| Date |
2005-07-12T23:17:00Z
2005-07-12T23:17:00Z 2005 |
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| Description |
(Kinesiology) Thesis (M.Sc.) - School of Kinesiology - Simon Fraser University
Amyotrophic lateral sclerosis (ALS) is a human neurodegenerative disorder characterized by the selective death of neurons in spinal cord, brain stem and cortex. The pathogenesis of ALS is still unknown. Adducins (Add) are a family of cytoskeletal associated proteins. Recent studies have shown that protein levels of phosphorylated adducin (phospho-adducin, p-Add) are increased in spinal cord tissue from ALS patients. I have evaluated the distribution of p-Add imrnunoreactivity in spinal cords of mice over-expressing mutant human superoxide dismutase (mSOD), an animal model of ALS, and in control littermates. Spinal cords of mSOD mice having motoneuron loss exhibit significantly greater p-Add immunoreactivity in ventral horn and dorsal horn, compared to control animals. The findings demonstrate increased immunoreactivity of phosphorylated adducin in a murine model of ALS. This increased p-Add immunoreactivity may be evidence for aberrant phosphorylation events contributing to motoneuron loss in mSOD mice. |
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1167176 bytes
application/pdf |
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| Language |
en
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| Relation |
http://troy.lib.sfu.ca/search/t?SEARCH=Phospho-adducin+distribution+in+a+murine+transgenic+model+of+amyotrophic+lateral+sclerosis
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| Rights |
Copyright remains with the author
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| Title |
Phospho-adducin distribution in a murine transgenic model of amyotrophic lateral sclerosis
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| Type |
text
thesis |
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| Identifier |
http://ir.lib.sfu.ca/handle/1892/660
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