Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter
MSpace at the University of Manitoba
View Archive Info| Field | Value | |
| Contributor |
Czubryt, Michael (Physiology)
Dixon, Ian (Physiology) Jassal, Davinder (Medicine) Mesaeli, Nasrin (Biochemistry and Medical Genetics) |
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| Creator |
Ramjiawan, Angela
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| Date |
2010-09-10T23:04:04Z
2010-09-10T23:04:04Z 2010-09-10T23:04:04Z |
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| Identifier |
http://hdl.handle.net/1993/4160
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| Description |
PGC-1α regulates cardiac mitochondrial biogenesis and energy metabolic gene expression, thus transcriptional regulation of PGC-1α gene expression is of great importance in understanding metabolic gene expression in cardiac health and disease. We provide evidence that estrogen related receptor α (ERRα, which also plays a role in cardiac energy metabolism, regulates expression of the PGC-1α gene via direct interaction with the PGC-1α gene promoter. In the presence of an inverse agonist to ERRα PGC-1α gene expression was significantly decreased, while over-expression of ERRα increased PGC-1α gene expression. We have also demonstrated that expression of PGC-1α was down regulated in hypoxic cardiomyocytes due to histone deacetylation. Our data identify ERRα as a novel regulator of cardiac PGC-1α gene expression, and suggests that promoter deacetylation in hypoxia plays a role in reduced PGC-1α expression. These results reveal a new mechanism that may contribute to energetic derangement in the heart during ischemia and/or failure.
October 2010 |
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| Format |
682934 bytes
application/pdf |
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| Language |
en_US
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| Subject |
Cardiovascular Physiology
Molecular Pathophysiology |
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| Title |
Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter
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| ##plugins.schemas.dc.fields.degree.name## |
Physiology
Master of Science (M.Sc.) |
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